Clinical Oncology: Case Reports

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Rachel Stewart (USA) Author

stewart_164@ken.edu.com

Subjects of specialization
Surgery , Molecular Genetic Pathology, Medical Oncology, Ovarian Cancer

Affiliation
Markey Tumor Procurement Faculty, Markey Cancer Center, University of Kentucky College of Medicine, Lexington, Kentucky

Biography

Rachel L. Stewart, is an Assistant Professor in the Department of Pathology and Laboratory Medicine at the University of Kentucky. She also serves as Scientific Associate Director for the Biospecimen Procurement and Translational Pathology Shared Resource Facility of the Markey Cancer Center. She received her medical degree from Touro University and completed residency training and her PhD at the University of Kentucky. Dr. Stewart then completed fellowship at the University of Utah in Molecular Genetic Pathology. She is board certified in Anatomic and Clinical Pathology and Molecular Genetic Pathology.

Publications

Case Report Subscription

A Case Study of Precision Medicine: Next Generation Sequencing Compared with Oncoscan in a Patient with Breast Cancer in Kentucky

Author(s):

Rolf J Craven*, Kuey-Chu Chen, Steven Schwarze, Sydney Lay, Dana Napier and Rachel Stewart

Purpose: Precision medicine of tumors is designed to tailor treatment combinations to individual patients, targeting specific genotypes with corresponding inhibitors. The purpose of this study was to determine whether genotype predicted target gene expression-a critical parameter for treatment-and to test whether alternate modes of gene amplification could affect gene expression. Patients and methods: The cohort consisted of patients in Kentucky with recurrent breast cancer who were analyzed by nextgeneration sequencing. Tumors with amplifications in CCND1, AURKA, and MYC were then stained by immunohistochemistry. We subsequently selected a patient with triple-negative breast cancer for analysis by FISH, immunohistochemistry and OncoScan genome-wide copy number array. Results: The exten... view more»

Abstract HTML PDF

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