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Hindi Journal of Applied Bioinformatics & Computational BiologyISSN: 2329-9533
Rajakumar Sundaram Author
Subjects of specialization
Affiliation
Microbiology, Marine Biology, Genetic Disorders, Ocular Diseases
Department of Marine Biotechnology, Bharathidasan University, Tiruchirappalli, India
Biography
Rajakumar Sundaram is working as an Assistant Professor at the Department of Marine Biotechnology at the Bharathidasan University since Feb 2011. RajaKumar Sundaram's international experience includes various programs, contributions and participation in different countries for diverse fields of study and research interests reflect in his 36 publications in various national and international journals.
Publications
Research Article Subscription
Computational Simulation of Retinal Angiogenesis Pathway towards the Identification of Effective Therapeutic Target and Screening of Drug Leads from Marine Metabolites
Author(s): Umadevi Subramanian, Ayyasamy Pudukadu Munuswamy and Rajakumar Sundaram
Retinal angiogenesis is the leading cause of blindness and it is reported that discrete inhibition of proteins namely VEGF, PKCα, SRC, PARP, TGFβ1 and PAI1 would reduce the angiogenesis. This study primarily focused to find out the better therapeutic target among them by analyzing mathematical equations framed for the angiogenesis pathway. The results revealed that the ratio of the EC50 to IC50 was found less with PAI1 than all other targets, so as fewer doses is require achieving better therapeutic effect than that of others. Further, the study was focused to identify the drug leads (inhibitor to PAI1) from marine secondary metabolites. Molecular docking approach was used to identify the required marine metabolites follows screening of drug-liken... view more»
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