Rakesh Kumar Yadav Author
Subjects of specialization
Affiliation
Anti-HDV antibodies;
Department of IT Deoghat, Indian Institute of Information Technology Allahabad, Jhalwa, Prayagraj, U.P. India, India
My name is Rakesh Kumar Yadav I am from Department of IT Deoghat, Indian Institute of Information Technology Allahabad, Jhalwa, Prayagraj, U.P. India, India My area of interests are Anti-HDV antibodies;
Research Article Subscription
Author(s): Rakesh Kumar Yadav, Jayvant Harlikar, Jaidatta Deshmukh, Chetan M. Bhalgat, Dipak Thange, Hemant Birari, Manish Gangrade, Srinivas V Pullela and Vinod Acharya
Application of an LC–MS/MS Method in Quantification of Hexyl Chloroformate Content in Dabigatran Etexilate Mesylate
Abstract
A selective and sensitive liquid chromatography–mass spectrometry (AB SCIEX QTRAP 5500) method was developed for quantitative determination of genotoxic impurity, hexyl chloroformate, in drug substance. The method was developed by derivatizing the hexyl chloroformate (HCF) to complex compound hexyl benzylcarbamate (HBC) by reaction with benzylamine. This method provided good sensitivity for quantification of hexyl chloroformate at a concentration of 10 ppm in 10 mg/mL... view moreĀ»