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Hindi Clinical Oncology: Case Reports
Ran Kornowski Author
Subjects of specialization
Affiliation
Carboplatin; Allergic; Vasospastic
Department of Cardiology, Rabin Medical Center, Petah Tikva, Israel
Biography
Dr. Ran Kornowski, working in Department of Cardiology, Rabin Medical Center, Petah Tikva, Israel. Over the experience in Derm centre Dr. Ran Kornowski specializes in Carboplatin; Allergic; Vasospastic
Publications
Case Report Open Access
Carboplatin-induced Allergic Coronary Vasospastic Reaction (Kounis Syndrome)
Author(s): Osnat Itzhaki Ben Zadok, Inbar Nardi Agmon, Pablo Codner, Alona Zer, Baruch Brenner, Ran Kornowski, and Katia Orvin
We describe a case of carboplatin-induced allergic coronary vasospastic reaction manifesting as ST-elevation myocardial infarction (Kounis syndrome) in a 67-year old male with lung adenocarcinoma and underlying ischemic heart disease. Shortly after commencing his 2nd carboplatin cycle, the patient presented with acute bronchospasm and hemodynamic collapse, anterolateral ST-elevations, elevated cardiac biomarkers and apical akinesia. Following initial management with high-dose steroids, a coronary angiography was performed demonstrating obstructive lesion in his left anterior descending artery which was treated with percutaneous coronary intervention and stent placement. The patient demonstrated significant clinical improvement. This case highlights the diagnostic work-up and ... view more»
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