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Hindi Clinical Oncology: Case Reports
Rebecca Jeun Author
Subjects of specialization
Affiliation
Diabetic ketoacidosis; Alpelisib; Phosphoinositide-3 kinase inhibitor; Sodium-glucose transporter 2 inhibitors
Section of Endocrinology, Diabetes and Metabolism, Baylor College of Medicine, Houstan, Texas, USA
Biography
Dr. Rebecca Jeun is an endocrinologist in Houston, Texas. Endocrinologists treat disorders of the hormone-secreting glands that regulate countless body functions. These ailments include diabetes, thyroid ailments, metabolic and nutritional disorders, pituitary diseases, menstrual and sexual problems.
Publications
Case Report Subscription
Diabetic Ketoacidosis upon Initiation of Alpelisib: Two Case Reports
Author(s): Rebecca Jeun, Victor Lavis and Sonali Thosani
Background: Alpelisib is an isoform specific phosphoinositide 3 kinase inhibitor recently approved for use in hormone receptor positive metastatic breast cancer that has been shown to cause hyperglycemia in 31%-82% of patients in clinical trials to date. Two patients in clinical trials of alpelisib developed diabetic ketoacidosis and one case was reported two months after initiating alpelisib. Here, we present two cases of diabetic ketoacidosis that occurred within six weeks of initiating alpelisib.
Case presentation: The first case was a 55-year-old woman with a history of metastatic hormone-receptor positive breast cancer, on treatment with fulvestrant and alpelisib. She did not have a prior history of diabetes mellitus and presented to the ... view more»
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