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Rolf J Craven Author
Subjects of specialization
Affiliation
Molecular Biology, Cell Biology, Cancer Biology, Cell Signaling, Cell Proliferation
Department of Pharmacology and Nutritional Sciences, Markey Cancer Center, University of Kentucky College of Medicine, Lexington, Kentucky
Biography
Dr. Rolf J Craven has completed BS Biochemistry from Clemson University; and MS in Biochemistry from University of Illinois-Chicago; PhD Genetics University of North Carolina-Chapel Hill. Currently he is working in Department of Pharmacology and Nutritional Sciences, Markey Cancer Center, University of Kentucky College of Medicine, Lexington, Kentucky
Publications
Case Report Subscription
A Case Study of Precision Medicine: Next Generation Sequencing Compared with Oncoscan in a Patient with Breast Cancer in Kentucky
Author(s): Rolf J Craven*, Kuey-Chu Chen, Steven Schwarze, Sydney Lay, Dana Napier and Rachel Stewart
Purpose: Precision medicine of tumors is designed to tailor treatment combinations to individual patients, targeting specific genotypes with corresponding inhibitors. The purpose of this study was to determine whether genotype predicted target gene expression-a critical parameter for treatment-and to test whether alternate modes of gene amplification could affect gene expression. Patients and methods: The cohort consisted of patients in Kentucky with recurrent breast cancer who were analyzed by nextgeneration sequencing. Tumors with amplifications in CCND1, AURKA, and MYC were then stained by immunohistochemistry. We subsequently selected a patient with triple-negative breast cancer for analysis by FISH, immunohistochemistry and OncoScan genome-wide copy number array. Results: The exten... view more»
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