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S Y Yang Author
Subjects of specialization
Affiliation
Applied Microbiology, Applied Microscopy, Applied Mycology, Applied Physiology, Biomedical Research
University of Kansas School of Medicine, USA
Biography
Shang-You Yang received his medical education and practiced as a Fellowship Trained Orthopedic Surgeon in China before pursuing graduate and research training at University of Manitoba, Winnipeg, MB, Canada, and Wayne State University, Detroit, MI, USA. He was a William Robinson Postdoctoral Fellow of Arthritis Foundation, USA, followed by serving as an Assistant Professor of Orthopedic Surgery at Wayne State University School of Medicine (2002-2008) and Assistant Professor of Biomedical Engineering at Wayne State University College of Engineering (2003-2008).
Publications
Short Communication Open Access
Quiescent pluripotent stem cells reside within murine peripheral nerves and can be stimulated to proliferate by rhBMP2 or by nerve trauma
Author(s): M Heggeness and S Y Yang
A novel and distinct newly discovered source of pluripotent stem cells obtainable from the peripheral nerves of mouse, rat and human that are believed to solve the most vexing problems presently hampering efforts to apply the use of use of stem cells to safe and effective clinical treatments will be described. A large population of quiescent cells within peripheral nerves which in response to nerve injury or stimulation with the cytokine BMP2, proliferate and generate populations of pluripotent stem cells has been documented. The cells express Sox2, Klf4, Oct4 and c-Myc, the four transcription factors that confer embryonic pluripotency, as verified by double stain immunohistochemistry and by real time PCR.
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