Clinical Oncology: Case Reports

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Safi Afzal andSamy IMcFarlane Author

smcfarlane@downstate.edu

Subjects of specialization
cancer, cancer oncology, Carcinogenesis

Affiliation
Department of Medicine, Division of Endocrinology, Internal Medicine Residency Program Director, State University of New York, Downstate Medical Center, Brooklyn,

Biography

Dr. Samy I McFarlane is working as scientist and professor at Department of Medicine, Division of Endocrinology, Internal Medicine Residency Program Director, State University of New York, Downstate Medical Center, Brooklyn,. The author has specalization in cancer, cancer oncology, chemotherapy, Carcinogenesis, Chemotherapy

Publications

Case Report Subscription

A Rare Presentation Of Checkpoint Inhibitor Induced RTA

Author(s):

Andrew V Doodnauth, Miriam M. Klar, Zohra Malik, Krunal H Patel, Daniela Tello, Safi Afzal and Samy I McFarlane

Immune checkpoint inhibitors have opened a new era in the treatment of advanced malignancies, resulting in increased use and remarkable clinical responses. However, there has been an increase in the incidence of immune-related adverse events as a result of the immunologic effects of these therapies. Kidney immune-related adverse events incidence is reported as low at 2% to 5%1. Renal toxicity commonly described includes acute interstitial nephritis, minimal change disease, immune complex glomerulonephritis2. Renal tubular acidosis (RTA) has occasionally been reported but is uncommon. We report a patient with a known history of metastatic melanoma undergoing treatment with Ipilimumab + Nivolumab who developed an RTA and was successfully treated with stress dose ster... view more»

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