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Hindi Journal of Applied Bioinformatics & Computational BiologyISSN: 2329-9533
Sanjay Chhibber Author
Subjects of specialization
Affiliation
Applied and Medical Microbiology, Pseudomonas Aeruginosa, Bacteria Biofilms, Microbial Molecular, Biology Inflammation
Department of Microbiology, Punjab University, Chandigarh-160014, India
Biography
Sanjay Chhibber obtained his Ph.D (Microbiology) Panjab University, Chandigarh. He was warded for European Communities Postdoctoral fellowship in the area of Biotechnology, year 1992 by Government of India, Department of Science and Technology, New Delhi. ? Visiting Professor at the University of Northumbria, New Castle Upon Tyne, UK from September 2006 to 2009. ? Fellow AMI by Association of Microbiologists of India 2010. Member, The National Academy of Sciences, Allahabad, 2015. his main research area include Bacteriophages.
Publications
Research Article Subscription
In silico Analysis of CRISPR-Cas System in Klebsiella Species
Author(s): Veena Devi and Sanjay Chhibber
Horizontal gene transfer (HGT) is one of the most prominent factors in the spread of multidrug-resistance in Klebsiella. CRISPR-Cas system in bacteria is known to act as a barrier to the uptake of mobile genetic elements (MGE’s) from the surroundings. In sequenced bacterial genomes, only 40% are known to contain CRISPR-Cas. However, in Klebsiella species it seems to be well distributed. In this study we extensively analyzed the structure of CRISPR-Cas across eight genomes belonging to four species of Klebsiella. A total of 13 Loci were found to contain 245 spacers. Alongside the two known types, Type IE and Type IF CRISPR-Cas systems another type of CRISPR-Cas system was found to be present. These three types of systems appears to be extremely conserved in terms of sequences of su... view more»
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