Sapre JV Author
Subjects of specialization
Affiliation
Post-traumatic stress
Symbiosis Institute of Technology, Symbiosis International (Deemed University), Pune, MH 412 115, India
My name is Sapre JV I am from Symbiosis Institute of Technology, Symbiosis International (Deemed University), Pune, MH 412 115, India My area of interests are Post-traumatic stress
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Author(s): Gangrade MG, Deshpande NM, Gharat HP*, More SD, Shinde SS, Raval VK, Sapre JV and Alexander RT
A new method using high-performance liquid chromatography coupled with ultra violet detection was developed and validated for the simultaneous quantification of six high-boiling residual solvents-Acetic acid, N,N-dimethylformamide, Dimethyl sulfoxide, N, N-dimethylacetamide, N-methyl-2-pyrrolidone and Benzyl alcohol in drug substances. This paper describes the development and validation of a simple and efficient RP-HPLC method for the determination of these high boiling residual solvents. Quantitation limits for Acetic Acid is 1000ppm (1000 μg/g of API), for Dimethylsulfoxide is 400 ppm (400 μg/g of API), for N, N dimethylformamide is 70 ppm (70 μg/g of API), for Dimethylacetamide is 80 ppm (80 μg/g of API), for N-methyl-2-pyrrolidone is 40 ppm (... view moreĀ»