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Hindi Journal of Clinical & Experimental OncologyISSN: 2324-9110
Sarah S Knox Author
Subjects of specialization
Affiliation
Oncology, Biophysical signaling, Epigenetics, Epithelial mesenchymal transition, Systems biology
Department of Epidemiology, School of Public Health, Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, WV 26506, USA.
Biography
Sarah S Knox was working at Department of Epidemiology, School of Public Health, Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, WV 26506, USA. He has more than 40 publications. His current research area related to Oncology.
Publications
Review Article Subscription
Oncology and Biophysics: A Need for Integration
Author(s): Sarah S Knox and Richard HW Funk
Oncology and Biophysics: A Need for Integration
The mainstream view of cancer as a mutated cell that has become dysfunctional and multiplies out of control (the somatic mutation model) is much less consistent with extant data than the context dependent model. The latter focuses on interactions between the cell and its surrounding environment as the initiator and driver of malignancy. The genome wide epigenetic changes that precede cancer and confer risk for cancer, strongly suggest that multiple systems are affected by gene expression changes before tumors even manifest. This provides a partial explanation for cancer’s ability to adapt to targeted therapies as well as an ex... view more»
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