Sergio Tufik Author
Subjects of specialization
Affiliation
Psycobiology, Sleep Disorders , Sleep
Department of Psycobiology, Sleep Disorders Center, Universidade Federal de S
Sergio Tufik, MD, PhD, is a researcher and chairman of the Sleep Studies Center at UNIFESP. Dr. Tufik is also a researcher at the Research Incentive Fund Association (AFIP) in Brazil and at the Brazilian National Council for Scientific and Technological Development (cCNPq). He is a member of the World Association of Sleep Medicine and the European Sleep Research Society, among others.
Research Article Subscription
Author(s): Suelem Izumi, Fernando Flexa Ribeiro-Filho, Glaucia Carneiro, Sonia M Togeiro, Sergio Tufik and Maria Teresa Zanella
Objective: This study evaluated the influence of obstructive sleep apnea (OSA) on hypothalamic–pituitary–adrenal (HPA) axis aiming to identify the polysomnographic data associated with cortisol abnormalities.
Methods: Forty-one men referred for suspected OSA underwent polysomnography and were classified according to the apneahypopnea index (AHI) into control group (n=16) and OSA group (n=25). The assessment of the HPA axis function included low-dose (0.25 mg) dexamethasone suppression test, the circadian rhythm of salivary cortisol secretion and the measurement of urinary free cortisol (UFC) excretion in a 24-hour urine collection.
Results: No differences were found be... view moreĀ»