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Hindi Journal of Pharmaceutical Sciences & Emerging DrugsISSN: 2380-9477
Shelley C Fan Author
Subjects of specialization
Affiliation
Pharmacology, Pharmaceutical Sciences, Medicinal Chemistry, Drag reduction, Drug Therapy
Zosano Pharma, Inc., 34790 Ardentech Court, Fremont, CA 94555, USA
Biography
Shelley C Fan; Zosano Pharma, Inc., 34790 Ardentech Court, Fremont, CA 94555, USA. Keywords: Adverse Drug Reactions,Drug Action,Drug Delivery,Drug Discovery,Drug interaction,Drug Intoxication,Drug Therapy; Drug Transport and Delivery, Emerging Drugs, Medicinal Chemistry, Pharmaceutical Analysis, Pharmaceutical Design, Pharmaceutical Sciences, Pharmaceutics and Drug Design, Pharmacoepidemiological Studies, Pharmacognosy, Pharmacology
Publications
Research Article Open Access
Formulation Characterization of Parathyroid Hormone PTH (1-34)Coated on a Novel Transdermal Microprojection Delivery System:Water Determination
Author(s): Mahmoud Ameri, Shelley C Fan and Yuh Fun Maa
This study assessed the feasibility of determining the water content of the PTH (1-34) formulation coated on a novel transdermal microprojection delivery system, ZP-PTH. Thermogravimetric analysis (TGA) and Karl Fischer (KF) titration were used for water analysis.Headspace moisture was determined by internal vapor analysis and a hand-held moisture sensor. The moisture sorption isotherm was established by moisture sorption analyzer. PTH (1-34) API and formulation showed several weight-loss phases in TGA thermograms. Water loss is not a single-phase event, occurring over a wide temperature range. The typical water amount in a single ZP-PTH coated array is below the sensitivity of TGA and KF titration. Combining 20 coated array samples together in a single extract made KF analysis is possi... view more»
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