Advanced Biomedical Research and Innovation

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Shevchenko J Author

jShevchenko@hotmail.com

Subjects of specialization
Arthritic conditions, Bursa inflammation (Bursitis), Fibrositis (Fibromyalgia syndrome), Fractures, Kyphosis

Affiliation
Novosibirsk State University, Russia, Clinical Immunology, Novosibirsk, Russia

Biography

970: M. S. in Mathematics, Novosibirsk state university, Russia. Thesis: "Adams–Novikov spectral sequence in the theory of oriented cobordisms". 1992: Doctor of Sciences in Mathematics, Sobolev Institute of Mathematics, Novosibirsk,Russia. Thesis "Manifolds with split normal bundles, topological properties and some applications". Visiting positions: The Weizmann Institute of Science, Israel. 1992, 1996, 2004, 2005, 2007, 2010. Stanford University, USA. 1994, 2008, Fulbright Fellow. Ege University, Izmir, Turkey 1998. Auckland University, New Zealand 2002. Permanent position: leading research fellow in Sobolev institute of mathematics SB RAS, professor of Novosibirsk state university.

Publications

Short Communication Open Access

Dendritic cells expressing MHC epitopes reduce allo-reactivity in vitro

Author(s):

Valeriy Tereshchenko, Kurilin V, Shevchenko J, Maksyutov A and Sennikov S

Although immunosuppressive therapy of graft rejection and graft-versus-host disease significantly increases the chance of successful allograft survival, it is often accompanied by severe side effects such as opportunistic infections and cancers. Therefore, the development of biological approaches to induce antigen-specific immunological tolerance to transplanted organs and tissues might be promising. In this study, C57Bl/6 mice dendritic cells (DCs) transfected with CBA mice MHC epitopes to suppress alloantigen-induced immune response in vitro were used. It was found that C57Bl/6 DCs transfected with CBA mice MHC epitopes were capable to induce FoxP3+ Tregs and IL-10+CD4+ cells in autologous splenocyte cultures. Also, C57Bl/6 DCs transfected with CBA mice MHC epitopes suppressed the pro... view more»

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