Shiro Mizuno (Japan) Author

Case Report Open Access

A Case of Lung Adenocarcinoma Associated with Eosinophilic Sinusitis Induced by Pembrolizumab Administration

Author(s):

Yoko Ishige, Ryo Kato, Shohei Shinomiya*, Yutaka Takahara, Yuki Fujimoto, Taku Oikawa and Shiro Mizuno (Japan)
 

The frequency of immune checkpoint inhibitor (ICI) use in lung cancer chemotherapy has increased and has been associated with an increasing frequency of Immune-Related Adverse Events (IRAEs). Although IRAEs mainly include interstitial pneumonia, colitis, thyroid dysfunction and type 1 diabetes, other adverse events have been reported. Case: A 46-year old man was admitted to our hospital with chest pain. Computed Tomography (CT) of the chest showed a mediastinal nodule and osteolysis at the Th8 level. Lung adenocarcinoma was diagnosed from transbronchial biopsy during bronchoscopy, and expression of programmed death-ligand 1 was 95%, so chemotherapy with pembrolizumab monotherapy was started. After pembrolizumab administration, serum eosinophil count increased, and systemic fatigue appea... view more»

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