Shubham Pant Author
Subjects of specialization
Affiliation
cancer, cancer oncology, Carcinogenesis
Department of Investigational Cancer Therapeutics, U.S.A
Dr. Shubham Pant is an Associate Professor with a joint appointment in the Department of Investigational Cancer Therapeutics and the Department of Gastrointestinal Medical Oncology at the University of Texas MD Anderson Cancer Center. Dr. Pant is a key opinion leader in the fields of Phase 1 (Early drug development) and GI Cancers including pancreatic, biliary, gall bladder and colorectal cancer. He has an expertise in targeted therapy and Immunotherapy and has co-authored numerous peer-review articles and is a Section Editor for the Handbook of Targeted Therapy and Immunotherapy.
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Author(s): Amanda Parkes, Filip Janku, Shubham Pant and Neeta Somaiah
Abstract
Gastrointestinal Stromal Tumor (GIST) metastases occur in 18%- 47% of patients and most commonly involve the liver and peritoneum. Central Nervous System (CNS) and other sanctuary site metastases are rare, with only limited single patient case reports available in the literature. Given the availability of multiple effective treatments and longer life expectancy in patients with metastatic GIST, there is an increased likelihood of metastases to sanctuary sites including the CNS. We sought to characterize three GIST patients who developed these rare sanctuary site metastases between 2017-2018 during their course of therapy and compare their clinical features and molecular profiles, to add to current knowledge and highlight the need for clinicians to con... view moreĀ»