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Hindi Journal of Clinical & Experimental OncologyISSN: 2324-9110
Spencer B Gibson Author
Subjects of specialization
Affiliation
Mucoepidermoid carcinoma, Breast cancer, Prostate biomarker, Endometrial cancer
Department of Biochemistry and Medical Genetics, Faculty of Health Sciences, University of Manitoba, Canada
Biography
Spencer B Gibson was working in the Department of Biochemistry and Medical Genetics, Faculty of Health Sciences, University of Manitoba, Canada. He has more than 250 publications. His current research area related to osteoarthropathy.
Publications
Review Article Open Access
Mcl-1 is a Gate Keeper Regulating Cell Death in Cancer Cells
Author(s): Yongqiang Chen and Spencer B Gibson
Selectively inducing cancer cells to death is the goal of cancer therapy. The discovery of B-cell lymphoma 2 (Bcl-2) family members regulating apoptotic cell death of cancer cells revealed new targets for cancer therapy. Bcl-2 family members can be classified into pro-apoptotic members and anti-apoptotic members among which myeloid cell leukemia 1 (Mcl-1) plays unique roles in regulating cell death and survival in cancer cells. Mcl-1 has a short half-life due to its degradation by multiple E3 ubiquitin-ligases. Under hypoxic conditions, Mcl-1 is up-regulated by activation of growth factor receptor, EGFR promoting cell survival whereas, prolonged/severe hypoxia leads to deactivation of EGFR and Mcl-1 degradation by E3 ubiquitin -ligase FBW7 contributing to ce... view more»
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