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Hindi Journal of Nanomaterials & Molecular NanotechnologyISSN: 2324-8777
Stephan Harm Author
Subjects of specialization
Affiliation
Pharmaceutical Technology ,Biopharmaceutics
Department of Pharmaceutical Technology and Biopharmaceutics, University of Vienna, Althanstra
Biography
Stephan Harm is affiliated with the Department of Pharmaceutical Technology and Biopharmaceutics, University of Vienna, Althanstraße 14, 1090 Vienna, Austria. Stephan Harm has a specialization in Medicine, biomedicine, process engineering, blood purification.
Publications
Research Article Open Access
Polymyxin-Coated Nanostructured Materials: An Option for Sepsis Treatment
Author(s): Stephan Harm and Jens Hartmann
Polymyxin-Coated Nanostructured Materials: An Option for Sepsis Treatment
Objective:
Endotoxins (lipopolysaccharides, LPS) are among the main targets in extracorporeal therapies. LPS, which is the major component of the outer cell wall of Gram-negative bacteria, strongly induces inflammatory responses in humans at concentrations lower than 1 ng/kg body weight. Although the elimination of LPS is promising for the supportive therapy of sepsis and liver failure, endotoxin neutralization using endotoxin adsorbents is controversial. Earlier studies show that Polymyxin B (PMB) could be applied for endotoxin inactivation in blood. Aim of this study was to establish an adsorbent-based PMB rel... view more»
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