Steven M Mooney | Author | SciTechnol | Cell Biology: Research &

Steven M Mooney Author

smooney4@jhmi.edu 410-614-0120 | 410-614-0120

Subjects of specialization
Biochemistry and Molecular Biology,Cellular Pathology,Cell Tissue Studies,Cell Regeneration,Cell therapy

Affiliation
James Buchanan Brady Urological Institute, Department of Urology and Oncology

Biography

Steven M. Mooney, Ph.D Works in the James Buchanan Brady Urological Institute, Department of Urology and Oncology, Johns Hopkins University School of Medicine, 600 N. Wolfe St. 129B Marburg, Baltimore, MD 21287, USA

Publications

Short Communication Subscription

Chemotherapy Increases Aggressiveness of Prostate Cancer via Epithelial Mesenchymal Transition

Author(s):

John J Kim, James E Verdone and Steven M Mooney

Chemotherapy Increases Aggressiveness of Prostate Cancer via Epithelial Mesenchymal Transition

Although chemotherapy has been used as a major therapeutic weapon against advanced prostate cancer, overcoming drug resistance is still a major challenge. Cancer has been known to diminish therapeutic effect by several molecular mechanisms– increasing efflux by recruiting cell membrane pumps and limiting drug diffusion by constructing leaky vasculature. Moreover, recent studies suggest that long-term treatment with chemotherapy may have detrimental effects for patients presenting with solid tumors. Specifically, prostate cancer epithelial cells develop resistance t... view more»

DOI: 10.4172/2324-9293.1000105

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