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Sydney Lay Author
Subjects of specialization
Affiliation
Genitourinary Cancer, Thoracic Cancer, Medical Oncology, Gastrointestinal Cancer, Leukemia Chronic Lymphocytic
Department of Chemistry, Markey Cancer Center, University of Kentucky College of Medicine, Lexington, Kentuck
Biography
Dr. Sydney Lay has been working at the Department of Chemistry, Markey Cancer Center, University of Kentucky College of Medicine, Lexington, Kentuck. After being in the research field, his specialization is in Genitourinary Cancer, Thoracic Cancer, Medical Oncology and many more.
Publications
Case Report Subscription
A Case Study of Precision Medicine: Next Generation Sequencing Compared with Oncoscan in a Patient with Breast Cancer in Kentucky
Author(s): Rolf J Craven*, Kuey-Chu Chen, Steven Schwarze, Sydney Lay, Dana Napier and Rachel Stewart
Purpose: Precision medicine of tumors is designed to tailor treatment combinations to individual patients, targeting specific genotypes with corresponding inhibitors. The purpose of this study was to determine whether genotype predicted target gene expression-a critical parameter for treatment-and to test whether alternate modes of gene amplification could affect gene expression. Patients and methods: The cohort consisted of patients in Kentucky with recurrent breast cancer who were analyzed by nextgeneration sequencing. Tumors with amplifications in CCND1, AURKA, and MYC were then stained by immunohistochemistry. We subsequently selected a patient with triple-negative breast cancer for analysis by FISH, immunohistochemistry and OncoScan genome-wide copy number array. Results: The exten... view more»
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