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Hindi Journal of Applied Bioinformatics & Computational BiologyISSN: 2329-9533
Upendra N Dwivedi Author
Subjects of specialization
Affiliation
Bioinformatics, Biotechnology
Professor of Biochemistry & Director, Institute for Development of Advanced Computing, ONGC Centre for Advanced Studies, University of Lucknow, Lucknow-226007, Uttar Pradesh, India
Biography
Upendra N Dwivedi is Currently working as a Professor at Department of Biochemistry, Centre of Bioinformatics in the University of Lucknow. He received his Ph. D. Biochemistry from B.H.U., Varanas and he persudeM. Sc. Biochemistry B.H.U.from Varanasi. He worked as a Vice Chancellor in the University of Lucknow and Pro Vice Chancellor from University of Lucknow. Previously he worked as a Dean in Faculty of Science at Lucknow University.
Publications
Research Article Open Access
Anti-Angiogenic Potential of Secondary Metabolites against Tyrosine Kinase Domain of Vascular Endothelial Growth Factor Receptor-1: An in silico Approach
Author(s): Upendra N Dwivedi, Aleena Asif, Sameeksha Tiwari, Om Prakash and Veda P Pandey
Angiogenesis, i.e. formation of new blood vessels, is a key hallmark of tumor growth and progression. The tyrosine kinase (TK) domain of vascular endothelial growth factor receptor (TK-VEGFR-1) is reported as the key intracellular domain responsible for the downstream signalling leading to angiogenesis. Therefore, targeting TK domain of VEGFR-1 and blocking downstream signalling is considered as a promising approach in cancer therapy. Furthermore, in view of severe side effects exhibited by present day synthetic drugs, directed against TK domain of VEGFR-1, there is a worldwide effort to identify safer alternatives drugs, especially coming from natural sources. Keeping this perspective in mind, in the present paper, we have evaluated the anti-angiogenic potential of ADMET screened 18 al... view more»
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