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Valeriy Tereshchenko Author
Subjects of specialization
Affiliation
Arthritic conditions, Bursa inflammation (Bursitis), Fibrositis (Fibromyalgia syndrome), Fractures, Kyphosis
Novosibirsk State University, Russia, n Research Institute of Fundamental and Clinical Immunology, Novosibirsk, Russia
Biography
Valeriy Tereshchenko graduated from Novosibirsk State University in 2014. He is researcher in Research Institute of Fundamental and Clinical Immunology, Novosibirsk, Russia. He has 7 publications and H-index 1.
Publications
Short Communication Open Access
Dendritic cells expressing MHC epitopes reduce allo-reactivity in vitro
Author(s): Valeriy Tereshchenko, Kurilin V, Shevchenko J, Maksyutov A and Sennikov S
Although immunosuppressive therapy of graft rejection and graft-versus-host disease significantly increases the chance of successful allograft survival, it is often accompanied by severe side effects such as opportunistic infections and cancers. Therefore, the development of biological approaches to induce antigen-specific immunological tolerance to transplanted organs and tissues might be promising. In this study, C57Bl/6 mice dendritic cells (DCs) transfected with CBA mice MHC epitopes to suppress alloantigen-induced immune response in vitro were used. It was found that C57Bl/6 DCs transfected with CBA mice MHC epitopes were capable to induce FoxP3+ Tregs and IL-10+CD4+ cells in autologous splenocyte cultures. Also, C57Bl/6 DCs transfected with CBA mice MHC epitopes suppressed the pro... view more»
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