Veena Devi Author

Research Article Subscription

In silico Analysis of CRISPR-Cas System in Klebsiella Species

Author(s):

Veena Devi and Sanjay Chhibber

Horizontal gene transfer (HGT) is one of the most prominent factors in the spread of multidrug-resistance in Klebsiella. CRISPR-Cas system in bacteria is known to act as a barrier to the uptake of mobile genetic elements (MGE’s) from the surroundings. In sequenced bacterial genomes, only 40% are known to contain CRISPR-Cas. However, in Klebsiella species it seems to be well distributed. In this study we extensively analyzed the structure of CRISPR-Cas across eight genomes belonging to four species of Klebsiella. A total of 13 Loci were found to contain 245 spacers. Alongside the two known types, Type IE and Type IF CRISPR-Cas systems another type of CRISPR-Cas system was found to be present. These three types of systems appears to be extremely conserved in terms of sequences of su... view more»

Abstract HTML PDF