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Hindi Clinical Oncology: Case Reports
Victor Lavisand Sonali Thosani Author
Subjects of specialization
Affiliation
Diabetic ketoacidosis; Alpelisib; Phosphoinositide-3 kinase inhibitor; Sodium-glucose transporter 2 inhibitors
Department of Endocrine Neoplasia & Hormonal Disorders, University of Texas MD Anderson Cancer Center, Houston, Texas, USA
Biography
Dr. Sonali Thosani is an Assistant Professor in the Division of Endocrine Neoplasia and Hormonal Disorders at the University of Texas MD Anderson. She grew up in Oklahoma City and graduated summa cum laude from Oklahoma City University with a Bachelor of Arts and Science in Spanish and Biology.
Publications
Case Report Subscription
Diabetic Ketoacidosis upon Initiation of Alpelisib: Two Case Reports
Author(s): Rebecca Jeun, Victor Lavis and Sonali Thosani
Background: Alpelisib is an isoform specific phosphoinositide 3 kinase inhibitor recently approved for use in hormone receptor positive metastatic breast cancer that has been shown to cause hyperglycemia in 31%-82% of patients in clinical trials to date. Two patients in clinical trials of alpelisib developed diabetic ketoacidosis and one case was reported two months after initiating alpelisib. Here, we present two cases of diabetic ketoacidosis that occurred within six weeks of initiating alpelisib.
Case presentation: The first case was a 55-year-old woman with a history of metastatic hormone-receptor positive breast cancer, on treatment with fulvestrant and alpelisib. She did not have a prior history of diabetes mellitus and presented to the ... view more»
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