Clinical Oncology: Case Reports

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Wing-Lok Chan (Hong Kong) Author

winglok@hku.hk

Subjects of specialization
Breast cancer; Brain metastases; Pertuzumab; Trastuzumab; Neratinib

Affiliation
Department of Clinical Oncology, LKS, The University of Hong Kong, Hong Kong

Biography

Dr. Wing-Lok Chan, working in Department of Clinical Oncology, LKS, The University of Hong Kong, Hong Kong . Over the experience  in Derm centre Dr. Wing-Lok Chan specializes in Cutaneous leiomyosarcoma; Mohs surgery; Malignant tumor

Publications

Case Report Subscription

Systemic Treatment for Patients with HER2-Positive Breast Cancer and Brain Metastases

Author(s):

Wing-Lok Chan
 

There is no consensus on the treatment of brain metastases in patients with HER2-positive breast cancer. This article reported a patient attained long intracranial control and survival with the use of multiple anti-HER2 agents. Treatment of brain metastases in patients with HER2-positive breast cancer should involve both local therapies and systemic anti-HER2 agents. Radiotherapy and surgery can disrupt the blood-brain barrier. This, in turn, allows the larger molecules like trastuzumab and pertuzumab to penetrate through for better control in the brain metastases. Novel anti-HER2 agents including lapatinib, neratinib, trastuzumab emtansine (TDM1), trastuzumab deruxtecan (T-DXd) can penetrate the bloodbrain barrier and can attain significant improvement in the response of the brain meta... view more»

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