Advanced Biomedical Research and Innovation

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Wong Ly Author

wong@american.edu.in

Subjects of specialization
Arthritic conditions, Bursa inflammation (Bursitis), Fibrositis (Fibromyalgia syndrome), Fractures, Kyphosis

Affiliation
Maastricht University, Netherlands, Biomedical Engineering at the University of Melbourne, Australia

Biography

Wong Ly completed her Bachelor’s degree in Biomedical Engineering at the University of Melbourne, Australia and PhD at the University of Queensland, Australia focused on targeted gene therapy for cardiac regeneration. She was a postdoctoral fellow at CSIRO manufacturing at Victoria, Australia working on pluripotent stem cell reporter cell lines using genome editing. She is currently appointed as a postdoctoral researcher at the Department of Genetics and Cell Biology, Maastricht University, Netherlands, studying the pathogenicity of genetic variants of DCM in IPSC-cardiomyocytes using CRISPR/Cas9 technology

Publications

Short Communication Open Access

Investigating the pathogenicity of LMNA variants in human pluripotent stem cell-cardiomyocytes using CRISPR/Cas9 technology

Author(s):

Wong Ly

Dilated cardiomyopathy (DCM), which is characterized by dilation of left or both ventricles and systolic dysfunction, comprises many hospitalized cardiomyopathy cases and has major impact on public health. About 48% of DCM cases are familiar with over 60 causative genes identified to date. Among them, mutations in LMNA gene (encoding nuclear protein Lamin A/C) account for 6% of families with DCM. Modern sequencing technologies, e.g. whole-exome-sequencing (WES), has identified numerous genetic variants in LMNA gene, however the pathogenicity of these variants and the molecular mechanisms leading to DCM remain unknown. This project aims to utilize induced pluripotent stem cells (iPSC) as a model system to phenotypically characterize LMNA mutations causing DCM and to design novel genome e... view more»

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