Advanced Biomedical Research and Innovation

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Xiaoqiang Yao Author

yao2068@cuhk.edu.hk

Subjects of specialization
Applied Microbiology, Applied Microscopy, Applied Mycology, Applied Physiology, Biomedical Research

Affiliation
The Chinese University of Hong Kong, Hong Kong

Biography

Xiaoqiang Yao, Ph.D., is the Professor in the School of Biomedical Sciences, The Chinese University of Hong Kong. He is one of active scientists in the area of Ca2+ signaling and ion channels in cardiovascular system and cancer. His interest include Ca2+ signaling, TRP channel regulation, oxidative stress and atherosclerosis, stem cell-derived cardiomyocytes, and cancer progression.

Publications

Short Communication Open Access

Depletion of TM9SF4 promotes osteogenic differentiation of mesenchymal stem cells

Author(s):

Libo Yu and Xiaoqiang Yao

Cytoskeleton reorganization is a critical factor of mesenchymal stem cell (MSC) differentiation. The change of cytoskeleton is closely related with mechanical stress signals, which participate in MSCs lineage commitment. Usually, spread and flatten MSCs will undergo osteogenesis, while round cells will turn into adipocytes. Trans-membrane 9 superfamily member 4 (TM9SF4) belongs to the trans-membrane 9 superfamily and involves in phagocytosis in Dictyostelium discoideum and Drosophila. The lab has previously found that TM9SF4 can induce actin S-glutathionylation on Cys374, which leads to the de-polymerization of actin fibres and change the cytoskeleton.

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