Journal of Otology & RhinologyISSN: 2324-8785

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Yang JH Author

YangJH24@gmail.com

Subjects of specialization
Nose, Neck Surgery, Oral cancer, Skull, Eye vision

Affiliation
Central laboratory, Shenzhen, Guang Dong, China

Biography

Working at Central laboratory, Shenzhen, Guang Dong, Place of living is  China. Subjects of Specialization are Nose, Neck Surgery, Oral cancer, Skull, Eye vision.

Publications

Research Article Open Access

Promoter Methylation of Dual Specificity Phosphatase-6 Gene effect on Invasion and Metastasis of Nasopharyngeal Carcinoma

Author(s):

Yang JH and Zhang S

Objective: The dual-specificity phosphatase-6 (DUSP-6) is a member of dual-specificity protein phosphatase (DUSP) family, it can make residues of threonine and tyrosine dephosphorylate. In recent years, it was found that DUSP-6 is correlated with tumour generation and progress. In this study we have detected the effect of DUSP-6 gene methylation on invasion and metastasis of nasopharyngeal carcinoma.

Methods: RT-PCR and methylation-specific PCR are used to detect mRNA expression and methylation state of DUSP-6 gene in nasopharyngeal carcinoma tissues and CNE2 cell line. The changes of mRNA expression and methylation state of DUSP-6 gene, proliferation and invasion of cells were detected after 5-aza- 2’-deoxycytidine (5-aza-cdR) treat... view more»

DOI: 10.4172/2324-8785.1000307

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