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Hindi Endocrinology & Diabetes ResearchISSN: 2470-7570
Yang Liu Author
Subjects of specialization
Affiliation
Sciences, Medical Sciences
Cincinnati Children's Hospital Medical Center, Institute of Zoology Chinese Academy of Sciences, nstitute of Radiation
Biography
| Cincinnati Children's Hospital Medical Center, Institute of Zoology Chinese Academy of Sciences, nstitute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College |
Publications
Review Article Subscription
The Interaction between Metformin and Bile Acids in Metabolic Disease
Author(s): Jianting Li, Yang Liu and Shuguang Pang
Objective: To review the function of bile acids and the mechanism of metformin in lipid and glucose metabolism, and the interaction between metformin and bile acids.
Methods: PubMed and Google Scholar were searched using terms such as bile acid, lipid, glucose, metformin and type 2 diabetes. Additional relevant references were identified by reviewing the reference lists of articles.
Results: Bile acids are important molecules of regulating glucose and lipid metabolism through FXR and TGR5, while metformin through AMPK signaling pathway. Regulator role of metformin in glucose and lipid metabolism might be associated with bile acid metabolism.
Conclusions: Metformin as a welcomed antidiabetic dru... view more»
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