Spanish 
Chinese 
Russian 
German 
French 
Japanese 
Portuguese 
Hindi Journal of Pharmaceutics & Drug Delivery ResearchISSN: 2325-9604
Yannis Dotsikas Author
Subjects of specialization
Affiliation
Melatonin; Controlled release; Experimental design; Formulation; Matrix tablets
Department of Pharmacy, National and Kapodistrian University of Athens, Athens, Greece
Biography
| Yannis Dotsikas Department of Pharmacy, National and Kapodistrian University of Athens, Athens, Greece |
Publications
Research Article Open Access
Optimization of Controlled Release Matrix Formulations of the Chronobiotic Hormone Melatonin via Experimental Design
Author(s): Marilena Vlachou, Angeliki Siamidi, Sofia Konstantinidou and Yannis Dotsikas
Melatonin (MT) is a chronobiotic hormone synthesized by the pineal gland and has a significant role in the regulation of the circadian biological clock. In order to be administered as a drug, the time of melatonin release from its formulation is of great significance. To this purpose, controlled release matrix tablets (200 mg) of MT were developed by using D-optimal experimental design, including 1 categorical and 2 numerical factors, aiming at effecting its sustained release using a USP XXIII dissolution apparatus II at pH 1.2 and 7.4 media. The excipients selected are polyvinyl pyrrolidone (M.W.: 10.000 and 55.000), hydroxylpropyl Methylcellulose K15M and lactose monohydrate. The in vitro release data were fitted to the Korsmeyer-Peppas empirical equation;... view more»
Google Scholars / Researchers Sites
