Yoko Hashimoto | Author | SciTechnol | Endocrinology & Diabetes

Yoko Hashimoto Author

yokahashimoto@gmail.com

Subjects of specialization
Health , Religion

Affiliation
Dalhousie University Faculty of Medicine, First Nation and Inuit Health Branch, McGill University, Meno-Ya-Win Health

Biography

Dalhousie University Faculty of Medicine, First Nation and Inuit Health Branch, McGill University, Meno-Ya-Win Health Centre, Northern Ontario School of Medicine, Ottawa Hospital Research Institute, Sioux Lookout First Nations Health Authority, The Ottawa Hospital, University of Manitoba, University of Ottawa, University of Ottawa Faculty of Medicine, University of Ottawa, Department of Medicine, University of Ottawa, Department of Medicine

Publications

Review Article Open Access

Statins Cause Lifestyle-Related Diseases-Biochemical Mechanism

Author(s):

Yoko Hashimoto and Harumi Okuyama

While statins are being used worldwide for the prevention of cardiovascular diseases, statin users have an increased probability of developing diabetes, arteriosclerosis, and other lifestyle-related diseases. Here, we review the molecular mechanisms underlying the onset of osteoporosis, chronic kidney disease, type 2 diabetes, and arteriosclerosis, and lowered testosterone levels induced by statin use. Statins inhibit 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, which is a rate-limiting enzyme of the mevalonate pathway that generates geranylgeranyl diphosphate (GGPP), 7-dehydrocholesterol (7-DHC), and cholesterol. GGPP is essential for vitamin K2 (VK2) synthesis from ingested vitamin K1. 7-DHC is a precursor of vitamin D3 (VD3). VD3 and VK2 upr... view more»

DOI: 10.4172/2470-7570.1000122

Abstract HTML PDF