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Hindi Journal of Clinical & Experimental OncologyISSN: 2324-9110
Zaki Monawar Eisa Author
Subjects of specialization
Affiliation
Mucoepidermoid carcinoma, Cancer chemotherapy, Prostate biomarker, Endometrial cancer
Department of Pathology, King Fahad Central Hospital, Abu Ariesh, Saudi Arabia
Biography
Zaki Monawar Eisa was working in the Department of Pathology, King Fahad Central Hospital, Abu Ariesh, Saudi Arabia. He has more than 40 publications. His current research area related to pathology.
Publications
Research Article Open Access
Promoter Methylation and Loss of Expression of PTEN Gene in Breast Cancer Patients from Saudi Population
Author(s): Mohammad Shabbir Alam*, Ahmed Bin Ali Jerah, Jalaluddin Mohammad Ashraf, Kathamuthu Kumaresan, Zaki Monawar Eisa and Nabil Tadros Mikhail
Objective: PTEN, a tumor-suppressor gene, located on chromosome 10q23.3, is implicated in various types of cancer including breast cancer. The aim of this study is to investigate the promoter methylation, loss of expression and significance of PTEN gene in breast cancer and to determine the correlation between promoter methylation and gene expression.
Methods: Promoter methylation and loss of expression of PTEN gene were analyzed using methylation-specific PCR and immunohistochemical methods respectively. The chi square test is used to correlate the promoter methylation and gene expression with their clincopathologic parameters.
Results: We examined 53 breast cancer specimens and 10 normal tissues adjacent to tumor. ... view more»
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