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Hindi Journal of Nursing & Patient CareISSN: 2573-4571
Zhang Ju Author
Subjects of specialization
Affiliation
Nursing
PhD degree from Peking Union Medical College. After postdoctoral work, her research focuses on basic research and clinical transformation of pressure injury.
Biography
Ju Zhang, PhD, School of Nursing, Qingdao University. Dr.Zhang received her PhD degree from Peking Union Medical College. After postdoctoral work, her research focuses on basic research and clinical transformation of pressure injury. In addition, her research involves the molecular mechanism of the progression of pressure injury as well as the development of biofunctional dressings that can be applied to wound healing.
Publications
Special Issue Article Open Access
Application of LL-37-loaded hydrogel for deep tissue injury healing in mouse models
Author(s): Zhang Ju
Background: Deep tissue injury is a unique type of pressure injury, the consequences of which, result in the impairment of angiogenesis. There is a present and unmet need for clinically effective therapeutic options. The human antimicrobial peptide, LL-37, has been shown to enhance wound healing in chronic wounds. However, its low stability within the wound environment limits its overall efficacy. Methods: An injectable, biocompatible and thermosensitive chitosan hydrogel embedded with LL-37 (LL-37/CS hydrogel) was developed and the efficacy of these hydrogels on deep tissue injury in mouse models was investigated. Results: The cytotoxicity assay demonstrated that the LL-37/CS hydrogel did not affect Mouse embryonic fibroblast cells (NIH3T3) viability. Moreover, it displayed antimicrobi... view more»
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