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Hindi Journal of Otology & RhinologyISSN: 2324-8785
Zhang S Author
Subjects of specialization
Affiliation
Nose, Neck Surgery, Oral cancer, Skull, Eye vision
Department of Otolaryngology, Guang Ming New District People
Biography
Working at Department of Otolaryngology, Guang Ming New District People’s Hospital of Shenzhen, Place of living is China. Subjects of Specialization are Nose, Neck Surgery, Oral cancer, Skull, Eye vision.
Publications
Research Article Open Access
Promoter Methylation of Dual Specificity Phosphatase-6 Gene effect on Invasion and Metastasis of Nasopharyngeal Carcinoma
Author(s): Yang JH and Zhang S
Objective: The dual-specificity phosphatase-6 (DUSP-6) is a member of dual-specificity protein phosphatase (DUSP) family, it can make residues of threonine and tyrosine dephosphorylate. In recent years, it was found that DUSP-6 is correlated with tumour generation and progress. In this study we have detected the effect of DUSP-6 gene methylation on invasion and metastasis of nasopharyngeal carcinoma.
Methods: RT-PCR and methylation-specific PCR are used to detect mRNA expression and methylation state of DUSP-6 gene in nasopharyngeal carcinoma tissues and CNE2 cell line. The changes of mRNA expression and methylation state of DUSP-6 gene, proliferation and invasion of cells were detected after 5-aza- 2’-deoxycytidine (5-aza-cdR) treat... view more»
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