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Hindi Journal of Clinical Genomics
Zhou Q Author
Subjects of specialization
Affiliation
Epigenomics, Genomic DNA
Department of Biochemistry and Molecular Biology, Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, USA
Biography
Zhou Q, belonging to Department of Biochemistry and Molecular Biology, Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, USA. Interested in the field of Epigenomics; Genomic DNA.
Publications
Review Article Open Access
Emerging Techniques in Single-Cell Epigenomics and their Applications to Cancer Research
Author(s): Lo PK and Zhou Q
Epigenomics encompasses studies of the chemical modifications of genomic DNA and associated histones, interactions between genomic DNA sequences and proteins, the dynamics of the chromosomal conformation, the functional relationships between these epigenetic events, and the regulatory impacts of these epigenetic events on gene expression in cells. In comparison to current techniques that are only capable of characterizing average epigenomics features across bulk cell ensembles, singlecell epigenomics methodologies are emerging as powerful new techniques to study cellular plasticity and heterogeneity, as seen in stem cells and cancer. Here we summarize available techniques for studies of single-cell epigenomics, review their current applications to cancer research, and discuss future pos... view more»
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