Zhou Yangxing Author
Subjects of specialization
Affiliation
Functionality-related characteristics (FRC); Hydroxypropyl methylcellulose (HPMC); Apparent viscosity; Degree of substitution for Hydroxypropyl content; Dissolution testing
Department of Formulation Development, Beijing Sciecure Pharmaceuticals Co., Ltd., Beijing, China 101301
| Zhou Yangxing Department of Formulation Development, Beijing Sciecure Pharmaceuticals Co., Ltd., Beijing, China 101301 |
Research Article Subscription
Author(s): Himankar Baishya, Zhou Yangxing, Wangshengmin and Lin Shao Hui
The Influence of HPMC Viscosity and %HPC Content as FRC Parameter on the Release of Highly Soluble Drug from Hydrophilic Matrix Tablets
Abstract
Extended-Release modified dosage forms of Niacin were prepared using Hypromellose as rate controlling polymer. Previous studies have shown that hypromellose viscosity, hydroxypropoxyl content (%HP) and particle size are important material attributes that may impact the performance of ER matrix tablets, depending on the drug solubility and formulations. The aim of this study was to further examine the influence of critical material attributes (CMA) of hypromellose on... view more»