Journal of Liver: Disease & TransplantationISSN: 2325-9612

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Research Article, J Liver Dis Transplant Vol: 1 Issue: 2

Cerebral Expression of NKCC1 in Rats with Acute and Chronic Hyperammonemia

Martin Eefsen1*, Ben Vainer2, Hanne Cathrine Bisgaard3 and Fin Stolze Larsen1
1Department of Hepatology, Rigshospitalet, University Hospital of Copenhagen, Blegdamsvej 9, 2100 Copenhagen, Denmark
2Department of Pathology, Rigshospitalet, University Hospital of Copenhagen, Blegdamsvej 9, 2100 Copenhagen, Denmark
3Department of Cellular and Molecular Medicine, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3, 2200 Copenhagen, Denmark
Corresponding author : Martin Eefsen, MD
Department of Hepatology, Rigshospitalet, University Hospital of Copenhagen, Blegdamsvej 9, 2100 Copenhagen, Denmark
Tel: +45 3545 2121; Fax: +45 3545 2913
E-mail: [email protected]
Received: November 06, 2012 Accepted: December 30, 2012 Published: January 02, 2013
Citation: Eefsen M, Vainer B, Bisgaard HC, Larsen FS (2012) Cerebral Expression of NKCC1 in Rats with Acute and Chronic Hyperammonemia. J Liver: Dis Transplant 1:2. doi:10.4172/2325-9612.1000104

Abstract

Cerebral Expression of NKCC1 in Rats with Acute and Chronic Hyperammonemia

Acute Liver Failure (ALF) is a severe medical condition, primarily defined by high plasma-ammonia levels, multiorgan failure and development of Hepatic Encephalopathy (HE), while chronic liver failure is defined by chronic low level hyperammonemia and development of HE. Newly research showed that increased cerebral expression of the ion-channel Na+, K+, Cl- co-transporter I (NKCC1) is associated with brain edema development in several medical clinical conditions.

Keywords: Phos-NKCC1; Intracranial pressure; Bile duct ligation; Porta cava anastomosis; Aquaporin-4

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