Journal of Pharmaceutics & Drug Delivery Research ISSN: 2325-9604

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Research Article, J Pharm Drug Deliv Res Vol: 2 Issue: 1

Characterization of Ethylcellulose and Hydroxypropyl Methylcellulose Microspheres for Controlled Release of Flurbiprofen

Muhammad Sajid Hamid Akash1,2*, Furqan Iqbal33, Musa Raza4, Kanwal Rehman1, Shabbir Ahmed4, Yasser Shahzad5 and Syed Nisar Hussain Shah3
1Institute of Pharmacology, Toxicology and Biochemical Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University Hangzhou, China
2College of Pharmacy, Government College University Faisalabad, Pakistan
3Faculty of Pharmacy, Bahauddin Zakariya University Multan, Pakistan
4Department of Pharmacy, The University of Lahore, Pakistan
5Division of Pharmacy and Pharmaceutical Sciences, School of Applied Sciences, University of Huddersfield, UK
Corresponding author : Muhammad Sajid Hamid Akash
College of Pharmacy, Government College University Faisalabad, Faisalabad, Pakistan
E-mail: [email protected]
Received: December 03, 2012 Accepted: January 30, 2013 Published: February 04, 2013
Citation: Akash MSH, Iqbal F, Raza M, Rehman K, Ahmed S, et al. (2013) Characterization of Ethylcellulose and Hydroxypropyl Methylcellulose Microspheres for Controlled Release of Flurbiprofen. J Pharm Drug Deliv Res 2:1. doi:10.4172/2325-9604.1000113

Abstract

Characterization of Ethylcellulose and Hydroxypropyl Methylcellulose Microspheres for Controlled Release of Flurbiprofen

The objective of this study was to design and optimize polymeric microspheres of flurbiprofen (FLB) with ethylcellulose (EC) and hydroxypropyl methylcellulose (HPMC) using response surface methodology. EC and HPMC were taken as independent variables whereas; the dependent variables were % drug release at pH 1.2, 4.5 and 7.4. FTIR spectra and TGA showed no significant difference between drug and polymers. DSC and XRD studies exhibited molecular dispersion of FLB within microspheres. Contour plots were drawn to predict the relationship between dependent and independent variables. Both polymers revealed their significant effects on drug release that followed the zero order which was further verified by the lowest values of Akaike information criterion. The mechanism of drug release followed super case II type of drug release. This study helped unraveling the influence of two factors on in-vitro drug release and thereby, proposed an appropriate sustained drug release formulation.

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