Journal of Proteomics & EnzymologyISSN: 2470-1289

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Review Article, J Proteomics Enzymol Vol: 4 Issue: 2

Characterization of Protein Complexes and Their Implication in Biological Processes

Mohamed Abu-Farha*, Kazem Behbehani and Jehad Abu baker*
Department of Biochemistry and Molecular Biology Unit, Dasman Diabetes Institute, Kuwait City, Kuwait
Corresponding author's : Mohamed Abufarha
Department of Biochemistry and Molecular Biology Unit, P.O. Box 1180, Dasman 15462, Kuwait
Tel: +965 2224 2999
E-mail: [email protected]
Jehad Abubakr
PhD. Biochemistry & Molecular Biology Unit, P.O. Box 1180, Dasman 15462, Kuwait
Tel: +965 2224 2999 Ext. 3563
E-mail: [email protected]
Received: August 01, 2015 Accepted:August 20, 2015 Published: August 25,2015
Citation: Abu-Farha M, Behbehani K, baker JA (2015) Characterization of Protein Complexes and Their Implication in Biological Processes . J Proteomics Enzymol 4:2. doi:10.4172/2470-1289.1000122

Abstract

In the post human genome era the focus has shifted to the field of proteomics. One focus of proteomic is the identification of proteinprotein interaction networks. In the past decade this approach has been applied to identify interactomes of many small organisms as well as humans. The mapping of these networks has proven useful and extending this approach to identify the human interactome will be pivotal to our understanding of proteins functions and their cellular and molecular role in diseases. Ultimately this understanding can be translated into effective drug discovery and disease therapy. However, the large number of proteins and their variants and the difficulty in manipulating these proteins poses a serious obstacle that needs to be over passed. In this article we will discuss the current state of the human interactome and the techniques used for mapping protein interaction networks and the possible ways to advance the mapping of the human interactome

Keywords: Protein-protein interaction; Protein mapping; Protein complexes

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