Endocrinology & Diabetes ResearchISSN: 2470-7570

Reach Us +12097300872
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Review Article, J Physiobiochem Metab Vol: 2 Issue: 2

Cytochrome P4502E1 and Other Xenobiotics Metabolizing Isoforms in Pathogenesis of Male Reproductive Disorders

Abstract

Cytochrome P4502E1 and Other Xenobiotics Metabolizing Isoforms in Pathogenesis of Male Reproductive Disorders

Last decades investigations demonstrated significant decreasing of men fertility and sperm quality. Approximately, 50% clinically confirmed infertility cases are attributed to the male partners. Male infertility pathogenesis is investigated insufficiently; its direct interrelation with such pathologies as varicocele or urogenital infections was demonstrated only in 23% of cases. At present, it is supposed that different etiologic factors (including idiopathic) could start similar processes, which final result would be spermatozoids quality, and/or quantity decreasing. The present review discusses possible impact of cytochrome P-450 xenobiotics modulation effects directly in male reproductive organs, suggesting it as one of the mechanisms of subfertility development.

Keywords: Male reproductive disorders; Testes; Cytochrome Р-450; Xenobiotics

Track Your Manuscript

Share This Page

Media Partners