Journal of Pharmaceutics & Drug Delivery Research ISSN: 2325-9604

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Rapid Communication, J Pharm Drug Deliv Res Vol: 3 Issue: 2

Design and Evaluation of a Multi Layer Tablet System Based on Dextran

Efentakis M* and Siamidi A
Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Athens, Greece
Corresponding author : Manolis Efentakis
Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Athens, Panepistimiopolis, Zografou, 157 71 Athens, Greece
Tel: +30 210 7274025; Fax: +30 210 7274 027
E-mail: [email protected]
Received: June 23, 2014 Accepted: August 13, 2014 Published: August 16, 2014
Citation: Efentakis M, Siamidi A (2014) Design and Evaluation of a Multi Layer Tablet System Based on Dextran. J Pharm Drug Deliv Res 3:2. doi:10.4172/2325-9604.1000123

Abstract

 In this investigation we have developed a core-in-cup system to provide pulsatile delivery. The system consisted of a core three layer tablet, containing the drug and an impermeable coating outer shell containing Dextran. All formulations displayed a lag time of 120- 240 mins. Depending on the structure of the system and its constituents. Drug release varied depending on the structure and its ingredients.

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