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Journal of Otology & RhinologyISSN: 2324-8785

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Research Article, J Otol Rhinol Vol: 2 Issue: 1

Dual Time Point PET Imaging in Head and Neck Squamous Cell Carcinoma

Sanaz Harirchian1*, Arjuna B Kuperan1, Nasrin Ghesani2 and Erik G Cohen1
1Department of Otolaryngology - Head & Neck Surgery, University of Medicine and Dentistry of New Jersey – New Jersey Medical School, Newark, NJ, USA
2Department of Nuclear Medicine, University of Medicine and Dentistry of New Jersey – New Jersey Medical School , Newark, NJ, USA
Corresponding author : Sanaz Harirchian
Department of Otolaryngology - Head & Neck Surgery, University of Medicine and Dentistry of New Jersey – New Jersey Medical School, 90 Bergen Street, Suite 8100, Newark, NJ 07103, USA
Tel: 9739724588; Fax: 9739723767
E-mail: [email protected]
Received: December 11, 2012 Accepted: February 01, 2013 Published: February 07, 2013
Citation: Harirchian S, Kuperan AB, Ghesani N, Cohen EG (2013) Dual Time Point PET Imaging in Head and Neck Squamous Cell Carcinoma. J Otol Rhinol 2:1. doi:10.4172/2324-8785.1000112

Abstract

Dual Time Point PET Imaging in Head and Neck Squamous Cell Carcinoma

Objective: Dual time point 18F-fluorodeoxyglucose -positron emission tomography (DTP-PET) is a technique which may detect malignancy more accurately than standard PET/CT imaging. Our main objective was to perform a pilot study to evaluate the characteristics of DTP-PET in primary head and neck squamous cell carcinomas (HNSCC) and lymph node metastases.
 
Study design: Case series
 
Setting: University hospital tertiary care center
 
Subjects and methods: 35 patients with previously untreated HNSCC underwent preoperative PET/CT at two time points (mean 41 minute time difference) from 2007-2010. Mean and maximum standardized uptake values (SUV) were measured for the primary lesion and cervical lymph node metastases at both times points and change in SUV over time was calculated. An SUV increase of 10% was used as the threshold for positivity.
 
Results: 30 of 35 primary tumors (86%) were positive by DTPPET with an average increase in maximum SUV of 28%. 16 of 21 lymph node metastases (76%) were positive by DTP-PET with an average increase in maximum SUV of 35%. Change in mean SUV did not correlate as well with the presence of tumor.
 
Conclusion: 86% of primary tumors and 76% of cervical lymph node metastases showed an increase in maximum SUV over time. These findings justify further study of DTP-PET as a method of detecting tumor in initial staging and restaging of HNSCC after treatment to improve the accuracy of standard PET/CT.

Keywords: Mucocele; Paranasal sinus mucocele; Frontal sinus obliteration;Functional endoscopic sinus surgery

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