Dr. Jorgensen is an Assistant Professor at Lerner Research Institute at the Cleveland Clinic, located in Cleveland, Ohio, USA. She trained in immunology with a specific focus on the etiology of Systemic Lupus Erythematosus in the labs of Dr. Brian Kotzin and Philippa Marrack. Her lab studies multiple well-established mouse models of SLE focusing on gender differences, immune modulating factors, and type I interferon. Her early studies identified the important role type I interferons play in disease development in lupus-prone mice, while more recently her lab described how plasmacytoid dendritic cells; major producers of type I interferons, are crucial for the initiation and early progression of disease in lupus-prone mice. Other studies from her lab have identified how the male sex hormone testosterone drives a population of immune-inhibitory myeloid cells essential for controlling disease initiation in male lupus-prone mice. She remains focused on unraveling potential new areas for therapeutic targeting in SLE-patients and have recently engaged in a set of translational studies in collaboration with the Dept. of Rheumatology at the Cleveland Clinic.

Lupus