Journal of Pharmaceutics & Drug Delivery Research ISSN: 2325-9604

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Research Article, J Pharm Drug Deliv Res Vol: 1 Issue: 1

Efavirenz Loaded Novel Citric Acid Dendritic Architecture for Increased Solubility and Sustained Delivery

Vijayarajkumar P1*, Ram Kumar Choudhary2 and Rakesh Narne3
1Faculty of Pharmacy, UCSI University, Jalan Menara Gading, 56000 Cheras, Kuala Lumpur, Malaysia
2Faculty of Pharmacy, Government Pharmacy Institute, Agamkuan, India
3Bharat Institute of Technology (Pharmacy), Mangalpally, Ibrahimpatnam, R.R. District, A.P-501510, India
Corresponding author : Palanirajan Vijayarajkumar
Faculty of Pharmacy, UCSI University, Jalan Menara Gading, 56000 Cheras, Kuala Lumpur, Malaysia
E-mail: [email protected]
Received: March 15, 2012 Accepted: June 23, 2012 Published: June 25, 2012
Citation: Vijayarajkumar P, Ram Kumar C, Rakesh N (2012) Efavirenz Loaded Novel Citric Acid Dendritic Architecture for Increased Solubility and Sustained Delivery. J Pharm Drug Deliv Res 1:1. doi:10.4172/2325-9604.1000103

Abstract

Efavirenz Loaded Novel Citric Acid Dendritic Architecture for Increased Solubility and Sustained Delivery

The present studies were aimed at developing and exploring the use of citric acid dendritic nanostructure for the solubilization and sustained delivery of an anti-viral drug, efavirenz. The citric acid dendritic nanostructure was synthesized and characterized by using IR and NMR spectroscopy. Efavirenz was efficiently loaded into citric acid dendritic nanostructure using dissolution process. Various physicochemical and physiological parameters such as UV, IR, DSC, NMR, SEM, drug loading, solubilization and in-vitro release concerning the citric acid dendritic nanostructure were evaluated.

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