Research Article, J Otol Rhinol S Vol: 0 Issue: 1
Effectiveness of Glucocorticosteroid for Postoperative Recurrence of Nasal Polyps in Chronic Rhinosinusitis associated with Asthma
|Katsuhisa Ikeda*, Takeshi Kusunoki, Tatuya Saitoh, Toru Yao,Kaori Kase, Akira Minekawa, Ayako Inoshita, Hidenori Yokoi and Kenji Kawano|
|Department of Otorhinolaryngology, Juntendo University Faculty of Medicine,Tokyo, Japan|
|Corresponding author : Katsuhisa Ikeda, MD
2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan
Tel: +81-3-5802-1094; Fax: +81-3-5689-0547
|Received: November 17, 2014 Accepted: January 16, 2015 Published: March 06, 2015|
|Citation: Ikeda K, Kusunoki T, Saitoh T, Yao T, Kase K, et al. (2015) Effectiveness of Glucocortico- steroid for Postoperative Recurrence of Nasal Polyps in Chronic Rhinosinusitis associated with Asthma. J Otol Rhinol S1:1. doi:10.4172/2324-8785.S1-002|
Backgrounds: Asthma co-mobidity is known to be associated with a poor prognosis for chronic rhinosinusitis with nasal polyps (CRSwNP). Systemic and topical glucocorticosteroid has been proved to be effective for recurrent nasal polyps after surgery.
Methods: We evaluated the steroid responsiveness and bacterial culture in 42 patients with CRSwNP associated with asthma during postoperative follow-up.
Results: Seventeen patients controlled by topical glucocorticosteroid therapy did not require systemic glucocorticosteroids (non-users). The remaining 25 patients showed recurrence of nasal polyps in spite of basal medication of topical corticosteroids and required oral corticosteroids. Eight patients were considered to be steroid non-responders. On the other hand, 17 patients responded to a short-term intake of oral corticosteroids (steroid responders). There was a statistically significant difference in the detection rate of pathogens from the sinus during acute exacerbations between steroid responders and non-users of steroids. There was a significant difference in symptomatic scores only between steroid non-responders and non-users of steroids, whereas the other parameters showed no significant differences.
Conclusion: Bacterial infection plays a critical role in recurrent polyps and refractory symptoms as well as in the poor response to glucocorticosteroids during postoperative followup. Keywords: Chronic