Journal of Pharmaceutics & Drug Delivery Research ISSN: 2325-9604

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Rapid Communication, J Pharm Drug Deliv Res Vol: 2 Issue: 2

Encapsulation of Fluoroquinolones in 1-Palmitoyl-2-Myristoyl- Phosphatidylcholine: Cholesterol Liposomes

Sousa Isabel and Gameiro Paula*
Requimte, Faculty of Science, University of Porto, Department of Chemistry and Biochemistry, Rua do Campo Alegre s / n, 4169-007 Porto, Portugal
Corresponding author : Gameiro Paula
Requimte, Faculty of Science, University of Porto, Department of Chemistry and Biochemistry, Rua do Campo Alegre s / n, 4169-007 Porto, Portugal
Tel: +351220402589
E-mail: [email protected]
Received: March 29, 2012 Accepted: March 11, 2013 Published: March 13, 2013
Citation: Isabel S, Paula G (2013) Encapsulation of Fluoroquinolones in 1-Palmitoyl-2-Myristoyl-Phosphatidylcholine: Cholesterol Liposomes. J Pharm Drug Deliv Res 2:1. doi:10.4172/2325-9604.1000114

Abstract

Encapsulation of Fluoroquinolones in 1-Palmitoyl-2-Myristoyl- Phosphatidylcholine: Cholesterol Liposomes

CQuinolones are a very well known class of antibacterial agents and, currently, one of the most prescribed drugs in medicine, therefore having a wide use in the treatment of several bacterial infections which seems to be the main cause for their bacterial resistance. With increasing menace of bacterial resistance, the development of new strategies to increase its efficacy is of great importance. Liposomes have been under study as drug delivery systems for the past years mainly due to their high biocompatibility in terms of composition, size and physicochemical properties.

Keywords: pH gradient; Spin columns; Norfloxacin; Levofloxacin; PMPC liposomes

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