Journal of Pharmaceutics & Drug Delivery Research ISSN: 2325-9604

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Research Article, J Pharm Drug Deliv Res Vol: 1 Issue: 3

Formulation, Optimization and Evaluation of Atorvastatin Calcium Loaded Microemulsion

Youjun Zhou 1, Shuangying Gui1,2*, Jian Wang3,4, Shanshan Qian1 and Enyuan Pan1
1Department of Pharmacy, Anhui University of Traditional Chinese Medicine, Shihe Road, Hefei, 230031, P.R,China
2Anhui Engineering Research Center for Chinese Medicine Preparation, Shihe Road, Hefei, 230031, P.R, China
3Anhui Key Laboratory of Modern Chinese Medicine & Materia, Shihe Road, Hefei, 230031, P.R, China
4Anhui“115”Xin’an Traditional Chinese Medicine Research & Development Innovation Team, 45 Shihe Road, Hefei, 230031, P.R, China
Corresponding author : Arvind Sharma
Chitkara College of Pharmacy, Chitkara University, Chandigarh-Patiala National Highway (NH-64) Punjab 140401, India
Tel
: + 01762505084; Fax: 01762505085
E-mail: [email protected]
Received: October 09, 2012 Accepted: November 23, 2012 Published: November 26, 2012
Citation: Sharma B, Sharma A, Arora S, Gupta S, Bishnoi M (2012) Formulation, Optimization and Evaluation of Atorvastatin Calcium Loaded Microemulsion. J Pharm Drug Deliv Res 1:3. doi:10.4172/2325-9604.1000109

Abstract

Formulation, Optimization and Evaluation of Atorvastatin Calcium Loaded Microemulsion

Atorvastatin calcium is a HMG-CoA inhibitor having an Antihyperlipidemic effect. It belongs to the II class of BCS classification hence formulating a microemulsion will increase its solubility/ dissolution and thus improves the oral bioavailability. Microemulsion formulation is prepared by water titration method using Labrafil M1944CS, Cremophor RH 40 and Transcutol HP as oil, surfactant and co-surfactant respectively. A single isotropic region, which is considered to be a bicontinuous microemulsion, is found in the pseudoternary phase diagrams developed at various ratios of Labrafil M1944CS, Cremophor RH 40 and Transcutol HP. The prepared microemulsion formulations are characterised for their thermodynamic stability, drug content, pH, percent transmittance, viscosity, conductivity, particle size determination, TEM analysis and in vitro release.

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