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Journal of Applied Bioinformatics & Computational BiologyISSN: 2329-9533

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Research Article, J Appl Bioinform Comput Biol Vol: 4 Issue: 1

Identification of Potent Inhibitor for RNA Dependent RNA Polymerase (RDRP) of Dengue Virus Serotype-3: A Molecular Docking Study

Sankarasubramanian J*, Pavithra KB and Kavitha B
Bioinformatics Infrastructure Facility, Maharani’s Science College for Women, Bangalore-560001, India
Corresponding author : Jagadesan Sankarasubramanian
Bioinformatics Infrastructure Facility, Maharani’s Science College for Women, Bangalore, India
Tel: +91-9566996939
E-mail: [email protected]
Received: July 07, 2014 Accepted: November 10, 2014 Published: November 17, 2014
Citation: Jagadesan Sankarasubramanian, Pavithra KB, Kavitha B (2015) Identification of Potent Inhibitor for RNA Dependent RNA polymerase (RDRP) of Dengue Virus Serotype-3: A Molecular Docking Study. J Appl Bioinform Comput Biol 4:1. doi:10.4172/2329-9533.1000113

Abstract

Identification of Potent Inhibitor for RNA Dependent RNA polymerase (RDRP) of Dengue Virus Serotype-3: A Molecular Docking Study

Dengue (RNA virus) virus belongs to the family of flaviviridae. It has four serotypes like DENV1, DENV2, DENV3, and DENV4. RNA dependent RNA polymerase (RdRP) is an enzyme that catalyses the replication of RNA from an RNA template and was taken as a target protein for our study. We have taken RdRP of the dengue virus serotype 3 with the PDB Id: 2J7W. Ribavirin, an antiviral drug which is a guanosine analogue for RNA viruses reported to inhibit dengue virus replication and amantadine which was also reported to have inhibitory effect over the replication proteins of dengue virus proteins have been taken as a target drug molecule in the current study. Entropy enthalpy hybrid docking was performed for the ligands against the RdRP protein and ribavirin was found to be the best ligand that can inhibit the RdRP effectively. Further study can be performed to prove the efficacy of the drug in inhibition of the DENV Proteins using wet lab/clinical techniques.

Keywords: Dengue virus; RDRP; Ribavirin; Docking; Flaviviridae; Amantadin

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