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Hindi Research Article, J Otol Rhinol Vol: 4 Issue: 2
Immunohistopathologic Distinctive Features of Primary and Recurrent Nasal Polyps
| Kamil Gel1, Ceren Günel2*, Ibrahim Meteoglu3 and Sema BaÃ?Â?ak H`2 | |
| 1Department of Otorhinolaryngology-Head and Neck Surgery, Marmaris State Hospital, MuÃ?Â?la, Turkey | |
| 2Department of Otorhinolaryngology-Head and Neck Surgery, Adnan Menderes University Medical Faculty, Ayd�±n, Turkey | |
| 3Department of Medical Pathology, Adnan Menderes University Medical Faculty, Ayd�±n, Turkey | |
| *Corresponding author : Ceren Günel Adnan Menderes Üniversitesi KBB AD, Aytepe Mevkii, 09100, Aydin, Turkey Tel: +90 533 7175693; Fax: + 90256 2182037 E-mail: drgunel@hotmail.com |
|
| Received: June 12, 2014 Accepted: November 10, 2014 Published: March 13, 2015 | |
| Citation: Gel K, Günel C, Meteoglu I, Basak HS (2015) Immunohistopathologic Distinctive Features of Primary and Recurrent Nasal Polyps. J Otol Rhinol 4:2. doi:10.4172/2324-8785.1000215 |
Abstract
Immunohistopathologic Distinctive Features of Primary and Recurrent Nasal Polyps
Background: The pathophysiology of recalcitrant form of nasal polyp (NP) can not be explained but it is believed to be multifactorial.
Objective: We aimed to characterize the distinctive immunohistopathologic features of primary and recalcitrant NPs and investigate the importance these features in predicting polyp recurrence.
Materials and Methods: Pathologic sections of 61 patients following primary or revision endoscopic sinus surgery for NP were analyzed. Immunohistochemical staining of primary antibodies; CD4, CD8, TGF-β, NF-kB, TNF-α, and VEGF were performed for all sections and evaluated for presence and staining degree. We also assessed eosinophilic infiltration in all specimens.
Results: The presence of eosinophils was 53.3% for patients with revision surgery and 46.7% for patients with primary surgery. There were significantly differences in presence of eosinophils between two groups (p = 0.048). 31.9% of patients in primary group, 68.1% patients in revision group had high tissue eosnophillia. There were significantly differences in eosinophil counts between primary and revision group (p = 0.45). There were no difference in presence and concentration of other markers between two groups (p<0.05).
Conclusion: Patients with histopathologically eosonophilia may have a tendency for recurrence of the disease. Potentially, patients with high tissue eosonophillia may benefit the most from postoperative corticosteroid therapy to prevent further recurrence.
