Journal of Otology & RhinologyISSN: 2324-8785

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Research Article, J Otol Rhinol Vol: 4 Issue: 2

Immunohistopathologic Distinctive Features of Primary and Recurrent Nasal Polyps

Kamil Gel1, Ceren Günel2*, Ibrahim Meteoglu3 and Sema Başak H`2
1Department of Otorhinolaryngology-Head and Neck Surgery, Marmaris State Hospital, Muğla, Turkey
2Department of Otorhinolaryngology-Head and Neck Surgery, Adnan Menderes University Medical Faculty, Aydın, Turkey
3Department of Medical Pathology, Adnan Menderes University Medical Faculty, Aydın, Turkey
*Corresponding author : Ceren Günel
Adnan Menderes Üniversitesi KBB AD, Aytepe Mevkii, 09100, Aydin, Turkey
Tel: +90 533 7175693; Fax: + 90256 2182037
E-mail: [email protected]
Received: June 12, 2014 Accepted: November 10, 2014 Published: March 13, 2015
Citation: Gel K, Günel C, Meteoglu I, Basak HS (2015) Immunohistopathologic Distinctive Features of Primary and Recurrent Nasal Polyps. J Otol Rhinol 4:2. doi:10.4172/2324-8785.1000215

Abstract

Immunohistopathologic Distinctive Features of Primary and Recurrent Nasal Polyps

Background: The pathophysiology of recalcitrant form of nasal polyp (NP) can not be explained but it is believed to be multifactorial.

Objective: We aimed to characterize the distinctive immunohistopathologic features of primary and recalcitrant NPs and investigate the importance these features in predicting polyp recurrence.

Materials and Methods: Pathologic sections of 61 patients following primary or revision endoscopic sinus surgery for NP were analyzed. Immunohistochemical staining of primary antibodies; CD4, CD8, TGF-β, NF-kB, TNF-α, and VEGF were performed for all sections and evaluated for presence and staining degree. We also assessed eosinophilic infiltration in all specimens.

Results: The presence of eosinophils was 53.3% for patients with revision surgery and 46.7% for patients with primary surgery. There were significantly differences in presence of eosinophils between two groups (p = 0.048). 31.9% of patients in primary group, 68.1% patients in revision group had high tissue eosnophillia. There were significantly differences in eosinophil counts between primary and revision group (p = 0.45). There were no difference in presence and concentration of other markers between two groups (p<0.05).

Conclusion: Patients with histopathologically eosonophilia may have a tendency for recurrence of the disease. Potentially, patients with high tissue eosonophillia may benefit the most from postoperative corticosteroid therapy to prevent further recurrence.

Keywords: Nasal polyp recurrence; Eosinophillia; CD4; TGF-��; NF.B; TNF-��; VEGF

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