Journal of Otology & RhinologyISSN: 2324-8785

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.
bahis siteleri bahis siteleri bahis siteleri casino siteleri

Research Article, J Otol Rhinol Vol: 4 Issue: 2

Immunohistopathologic Distinctive Features of Primary and Recurrent Nasal Polyps

Kamil Gel1, Ceren Günel2*, Ibrahim Meteoglu3 and Sema Ba�?�?ak H`2
1Department of Otorhinolaryngology-Head and Neck Surgery, Marmaris State Hospital, Mu�?�?la, Turkey
2Department of Otorhinolaryngology-Head and Neck Surgery, Adnan Menderes University Medical Faculty, Ayd�?±n, Turkey
3Department of Medical Pathology, Adnan Menderes University Medical Faculty, Ayd�?±n, Turkey
*Corresponding author : Ceren Günel
Adnan Menderes Üniversitesi KBB AD, Aytepe Mevkii, 09100, Aydin, Turkey
Tel: +90 533 7175693; Fax: + 90256 2182037
E-mail: drgunel@hotmail.com
Received: June 12, 2014 Accepted: November 10, 2014 Published: March 13, 2015
Citation: Gel K, Günel C, Meteoglu I, Basak HS (2015) Immunohistopathologic Distinctive Features of Primary and Recurrent Nasal Polyps. J Otol Rhinol 4:2. doi:10.4172/2324-8785.1000215

Abstract

Immunohistopathologic Distinctive Features of Primary and Recurrent Nasal Polyps

Background: The pathophysiology of recalcitrant form of nasal polyp (NP) can not be explained but it is believed to be multifactorial.

Objective: We aimed to characterize the distinctive immunohistopathologic features of primary and recalcitrant NPs and investigate the importance these features in predicting polyp recurrence.

Materials and Methods: Pathologic sections of 61 patients following primary or revision endoscopic sinus surgery for NP were analyzed. Immunohistochemical staining of primary antibodies; CD4, CD8, TGF-β, NF-kB, TNF-α, and VEGF were performed for all sections and evaluated for presence and staining degree. We also assessed eosinophilic infiltration in all specimens.

Results: The presence of eosinophils was 53.3% for patients with revision surgery and 46.7% for patients with primary surgery. There were significantly differences in presence of eosinophils between two groups (p = 0.048). 31.9% of patients in primary group, 68.1% patients in revision group had high tissue eosnophillia. There were significantly differences in eosinophil counts between primary and revision group (p = 0.45). There were no difference in presence and concentration of other markers between two groups (p<0.05).

Conclusion: Patients with histopathologically eosonophilia may have a tendency for recurrence of the disease. Potentially, patients with high tissue eosonophillia may benefit the most from postoperative corticosteroid therapy to prevent further recurrence.

Keywords: Nasal polyp recurrence; Eosinophillia; CD4; TGF-��; NF.B; TNF-��; VEGF

international publisher, scitechnol, subscription journals, subscription, international, publisher, science

Track Your Manuscript

Awards Nomination

Media Partners

Associations

open access