Journal of Pharmaceutics & Drug Delivery ResearchISSN: 2325-9604

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Research Article,  J Pharm Drug Deliv Res Vol: 3 Issue: 2

Inhibiting Human Lactate Dehydrogenase-C for Male Fertility Control; Initial Hits

Ranjna C Dutta1*, Nitin W. Fadnavis 2 and Erwin Goldberg1
1Biochemistry Molecular Biology and Cell Biology, Northwestern University, Evanston, IL-60208, USA
2Discovery Lab, Indian Institute of Chemical Technology, Hyderabad, India
Corresponding author : Ranjna C Dutta
12-5-149/16-2, Vijayapuri, South Lalaguda, Hyderabd-500017, AP, India
Received: March 18, 2014 Accepted: July 25, 2014 Published: October 2, 2014
Citation: Ranjna CD, Nitin WF, Erwin G (2014) Inhibiting Human Lactate Dehydrogenase-C for Male Fertility Control; Initial Hits. J Pharm Drug Deliv Res 3:2. doi:10.4172/2325-9604.1000125


 Lactate dehydrogenase-C (LDH-C) is an oxido-reductive enzyme of LDH (EC family which is present abundantly in testes, spermatocytes, spermatids and sperms. It plays an important role in maintaining glycolysis and ATP production in the flagellum during sperm capacitation, therefore essential for male fertility. Profuse expression exclusively in these tissues makes LDH-C a potential target for male contraceptive development. However, creating a specific inhibitor for LDH-C is challenging due to its extensive sequence similarity (84-89%) with somatic isozymes LDH-A and B.

Keywords: Enzyme; High throughput screening (HTS); Inhibitors; Km; LDH; Vmax;

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