Journal of Pharmaceutics & Drug Delivery Research ISSN: 2325-9604

Reach Us +1 209 730 0872
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Research Article,  J Pharm Drug Deliv Res Vol: 3 Issue: 2

Inhibiting Human Lactate Dehydrogenase-C for Male Fertility Control; Initial Hits

Ranjna C Dutta1*, Nitin W. Fadnavis 2 and Erwin Goldberg1
1Biochemistry Molecular Biology and Cell Biology, Northwestern University, Evanston, IL-60208, USA
2Discovery Lab, Indian Institute of Chemical Technology, Hyderabad, India
Corresponding author : Ranjna C Dutta
12-5-149/16-2, Vijayapuri, South Lalaguda, Hyderabd-500017, AP, India
Tel:91-40-27007288
Email: [email protected]
Received: March 18, 2014 Accepted: July 25, 2014 Published: October 2, 2014
Citation: Ranjna CD, Nitin WF, Erwin G (2014) Inhibiting Human Lactate Dehydrogenase-C for Male Fertility Control; Initial Hits. J Pharm Drug Deliv Res 3:2. doi:10.4172/2325-9604.1000125

Abstract

 Lactate dehydrogenase-C (LDH-C) is an oxido-reductive enzyme of LDH (EC 1.1.1.27) family which is present abundantly in testes, spermatocytes, spermatids and sperms. It plays an important role in maintaining glycolysis and ATP production in the flagellum during sperm capacitation, therefore essential for male fertility. Profuse expression exclusively in these tissues makes LDH-C a potential target for male contraceptive development. However, creating a specific inhibitor for LDH-C is challenging due to its extensive sequence similarity (84-89%) with somatic isozymes LDH-A and B.

Keywords: Enzyme; High throughput screening (HTS); Inhibitors; Km; LDH; Vmax;

Track Your Manuscript

Share This Page